GHK-Cu, the copper-binding complex of glycyl-L-histidyl-L-lysine, has emerged as a pivotal molecule in regenerative research due to its dual role as a signaling peptide and copper transporter. This 50mg nasal spray formulation enables precise investigation of its:

• Tissue Remodeling Capacity: Stimulates collagen synthesis (types I, III, IV) while regulating MMP activity for balanced extracellular matrix deposition
• Anti-Inflammatory Mechanisms: Downregulates NF-κB pathway while enhancing TGF-β1 expression in wound models
• Systemic Copper Homeostasis: Provides bioavailable Cu²⁺ ions essential for superoxide dismutase (SOD) activity and antioxidant defense
• Epigenetic Modulation: Influences gene expression patterns in aged fibroblasts through chromatin remodeling

Advanced Delivery System

The nasal administration route offers:

• 90%+ bioavailability compared to topical application
• Direct access to systemic circulation via nasal mucosa
• Precision dosing (1mg/spray ±2% variance)
• Ideal for chronic exposure studies (14-28 day protocols)

Storage and Handling Protocol

• Optimal Storage: Maintain at 18-22°C in amber glass; copper-stabilized formulation ensures 24-month stability
• Aseptic Handling: Requires laminar flow hood for vial access; ethanol-wiped components

Research Administration

• Dosing Flexibility: Suitable for q12h-q24h regimens in tissue regeneration models
• Study Validation: HPLC-verified peptide purity (>98%) and copper content (12.7% w/w)