Cialis

Description

Tadalafil (50 x 20mg), marketed as Cialis®, is a selective phosphodiesterase type 5 (PDE5) inhibitor with multiple therapeutic applications:

Clinical Indications:
• Erectile dysfunction treatment (5-20 mg dosing)
• Benign prostatic hyperplasia symptom management (5 mg daily)
• Pulmonary arterial hypertension (40 mg daily)

Pharmacological Profile:

• Extended duration of action (up to 36 hours clinical effect)

• Rapid absorption (Tmax = 2 hours)

• High protein binding (94%)

• Hepatic metabolism via CYP3A4

Research Applications:

1. Vascular endothelial function studies

2. Lower urinary tract pathophysiology

3. Chronic pulmonary circulation research

4. Gender-specific vascular response analysis

Mechanistic Action:

• Potentiates nitric oxide-mediated vasodilation

• Increases smooth muscle cGMP concentrations

• Demonstrates tissue selectivity in urogenital vasculature

Current Research Focus:
✔ Dose optimization protocols
✔ Long-term vascular health impacts
✔ Combination therapy potential

Note: The compound requires sexual stimulation for therapeutic effect and is contraindicated with nitrate medications. Ongoing research investigates its pharmacokinetic profile and potential applications in vascular medicine. Available product may not match displayed product image.