Cialis

Tadalafil, marketed as Cialis®, is a selective phosphodiesterase type 5 (PDE5) inhibitor with multiple therapeutic applications:

Clinical Indications:
• Erectile dysfunction treatment (5-20 mg dosing)
• Benign prostatic hyperplasia symptom management (5 mg daily)
• Pulmonary arterial hypertension (40 mg daily)

Pharmacological Profile:

• Extended duration of action (up to 36 hours clinical effect)

• Rapid absorption (Tmax = 2 hours)

• High protein binding (94%)

• Hepatic metabolism via CYP3A4

Research Applications:

1. Vascular endothelial function studies

2. Lower urinary tract pathophysiology

3. Chronic pulmonary circulation research

4. Gender-specific vascular response analysis

Mechanistic Action:

• Potentiates nitric oxide-mediated vasodilation

• Increases smooth muscle cGMP concentrations

• Demonstrates tissue selectivity in urogenital vasculature

Current Research Focus:
✔ Dose optimization protocols
✔ Long-term vascular health impacts
✔ Combination therapy potential

Note: Contraindicated with nitrate medications. Therapeutic effects require sexual stimulation for ED applications.