OXYTROP Human Growth Hormone use is a new and quickly growing drug in the recreational performance enhancement drug market, and all the rave when it comes to Peptides. Growth Hormone or Somatotropin is an Amino Acid chain that can have muscle building, fat loss, and longevity effects on the body – depending on how you use it of course. To see how you should use it for its specific effects, keep on reading.
What is Growth Hormone?
While the name rings true that Human Growth is important for the growth and development of cells, the real purpose of Human Growth Hormone becomes apparent when looking at cell development and cell regeneration. Growth Hormone is a natural Amino Acid chain (peptide) that is produced by the pituitary gland. In the medical field, synthetic HGH can be used to treat individuals who are suffering from an HGH deficiency, muscle wastage, or recovering from serious injury.
The HGH we make use of today is manufactured with bacteria, compared to the HGH of old that was manufactured using cadavers. Synthesized Human Growth Hormone can be used for a myriad of different effects such as muscle growth and fat loss.
How does Growth Hormone work?
Endogenously, Human Growth Hormone is produced in response to the release of growth hormone-releasing hormone (GHRH) from the hypothalamus and is controlled via somatostatin. The former enables the release of HGH in pulses whilst the latter inhibits the release.
The body will continue releasing Growth Hormone (in pulses) to about one and two milligrams of the hormone per day. This means the body does not really produce a lot of Growth Hormone, and these levels will actually begin to steadily decline after the age of 30.
When taken exogenously, HGH can have some staggering effects on the body. It can lead to the following:
- Increase in Fat Loss: Growth Hormone is often used as a treatment for obesity as it can cause an increase in Lipase, which will cause a breakdown of Adipocytes into Free Fatty Acids.
- Nitrogen Efficiency: Studies have shown that in periods where physical activity is lowered due to injury, HGH can lead to a decrease in Protein Breakdown.
We know these mechanisms for HGH do exist, but in reality, using them for either of these will need some serious timing work.
Growth Hormone for Fat Loss
Growth Hormone is often used by bodybuilders and even recreational lifters for its fat loss capabilities. This might be better than traditional fat loss agents (such as stimulants) because it works differently, doesn’t cause any jitters, and might actually help with muscle retention as well. How exactly does Growth Hormone cause Fat Loss?
- Growth Hormone enters the bloodstream and begins circulating.
- It reaches the pancreas, which in turn releases Lipase.
- Lipase is a hormone that will release fatty cells from Adipocytes into the blood as Free Fatty Acids*
* This will mostly be done by lipoprotein lipase (LPL) which is produced not just by the Pancreas, but also by adipose tissue, cardiac and skeletal muscle, islets, and macrophages.
HGH has also been shown to be extremely good at lowering fat in the abdominal area, especially visceral fat. This makes it a very effective fat burner, even amongst people who are not looking for performance enhancement. While there is very little science to actually back the timing of dosage, most bodybuilders know that to get the most amount of fat loss results, it is best to take Growth Hormone before early morning fasted cardio.
- Males: 2 – 4 Units per day
- Females: 1 – 3 Units per day
Growth Hormone for Muscle Gain
The use of Growth Hormone in the pursuit of muscle mass is not a route often taken. Many will attest to the fact that Androgens such as Testosterone and Nandrolone Decanoate are better at building muscle than Growth Hormone. There is research to prove this, but there is also a growing number of users that are eager to say that Growth Hormone will greatly increase the effectiveness of other compounds such as Steroids, SARMs and Insulin.
That being said, for Growth Hormone to have any real effect on muscle mass, you’re looking at using it for a very long time – 6 – 8 months before you start seeing actual results. This is probably due to the fact that the growth will be primarily Sarcoplasmic compared to regular hypertrophy – the former of which can take its sweet time.
With that being said, amongst bodybuilders, the correct time to take HGH for maximal growth would have to be before bed, away from food.
Dosages for pure hypertrophy (advanced PED users can use very high amounts):
- Males: 2 – 6+ Units per day
- Females: 1 – 4 Units per day
The main side effect we associate with Growth Hormone usage is the fact that it can lead to insulin resistance. We know that having a deficiency in HGH can also lead to increased insulin resistance, but providing the body with way too much can lead to insulin resistance via the following methods:
- Phosphoinositide 3-kinase (PI3K) is negatively regulated by p85, which leads to less Glucose uptake into fat cells, meaning glucose stays in the blood
- HGH can release Free Fatty Acids from Adipocytes into the blood. Higher levels of Free Fatty Acids within the blood have been linked to insulin resistance
- An increase in Free Fatty Acids can cause hepatocytes to take more of these up. This in turn can lead to hepatic lipid oxidation and accumulation of acetyl Coenzyme A (Acetyl-CoA). Acetyl-CoA will then release glucose-6-phosphate as glucose (from the kidneys and liver) into the bloodstream which can further impact insulin resistance
People who have actually used HGH will know that while these situations are prominent in the medical field, they are far less common in trained individuals who follow somewhat of a healthy diet. Still, if you are looking for an Alternative to HGH that could lead to less Insulin Resistance results – MK-677 (IBUTAMOREN) is always an option.
Mk-677 is known as an Oral Ghrelin Mimetic, which will stimulate your Pituitary Gland to produce more natural Growth Hormone. It can be used as part of a PCT protocol after using Growth Hormone (which can suppress endogenous GH release), whilst many use it for different reasons. According to some anecdotal reviews, it won’t lead to the same level of Insulin Resistance Symptoms we associate with Human Growth Hormone.
HGH with Aromatisible Drugs?
Another unfortunate effect of HGH is the fact that it can interact with certain Anabolic Hormones; particularly the ones that have a strong affinity to Aromatise. HGH in and of itself does not cause an increase in Estrogen but will cause an increase in Prolactin levels. Prolactin is also secreted by the Pituitary gland and can cause some nasty side effects such as lactating nipples, ED, and excruciating body aches. You could manage this by monitoring your Estrogen and Prolactin levels very carefully, specifically managing your Prolactin with a drug like Mirapex (MIRAGEN).
HGH with T4?
T4 is the non-active hormone that is produced by the Thyroid, which converts to T3 and will largely dictate your metabolism, while influencing most other bodily functions. An increase in HGH has been shown to increase the conversion of T4 to T3, meaning that supplementing with exogenous T3 (CYTOMEL) might dramatically increase your fat loss efforts as T3 is actually often used by bodybuilders to increase their metabolism.